Factors Influencing Increases in CD4 Cell Counts of HIV/AIDS Patients Receiving Antiretroviral Therapy in Kupang, East Nusa Tenggara
Background: Antiretroviral therapy is the main treatment used in the management of HIV/AIDS. Antiretroviral therapy proved able to suppress viral replication and increase the number of CD4 T-cells so as to suppress the progression of the disease. CD4 + T cell counts is an important indicator to determining the level of immunity of the human body, maintaining the number of CD4+ T cells in normal limits to defend themselves from complications related to HIV/AIDS in particular to prevent opportunistic infections. The number of CD4+ T cells will determine when people living with HIV should begin antiretroviral therapy. Objective: To identify an increase in the number of CD4+ T cells in the first 12 months of ARV treatment and the factors that influence it. Methods: Retrospective longitudinal study design. Using the total sampling, all patients ARV therapy in January 2012 - December 2014, aged ≥ 17 years and provided the results of CD4+ T cell counts after getting ARV therapy within 12 months. Results: A total of 127 subjects in the study, most of the male sex (62.2%) and women (37.8%). The probability baseline of CD4 cell count at 200-350 cells mm3 increased 5.96 times more likely to achieve a CD4 T cell counts >350 cells/mm3 compared with levels of CD4 <200 cells/mm3 (p-value = <0.001, OR = 5, 96, CI = 2.20-16.12). Women 2.87 times higher increased CD4 >350 cells/mm3 compared to men (p-value = 0.049, OR = 2.87, CI = 1.01 to 8.27). Subjects who started therapy with body weight >46 kg has a probability of 3.40 times the increased value of CD4+ T cells >350 cells/mm3 compared to the start of therapy with body weight ≤46 kg (p-value = 0.025, OR = 3.40 CI = 1.16-9.97). Conclusion: A total of 18.9% of patients achieving CD4 T cell counts >350 cells/mm3 after one year of therapy. CD4 T cell count at the start of therapy is the only factor affecting the increase in the number of CD4 T cells up to >350 cells/mm3 after one year of therapy. Age, education level, gender, weight, Occupation, Group Risk, opportunistic infections, Stage Clinical and Supervisory taking medicine no significant effect on the increase in the number of CD4 T-cells up to >350 cells/mm3.