Antihiperglicemic Activity Tests OF Tamarillo (Solanum Betaceum) on Aloksan's Diabetes Rats

  • Ni Nyoman Yuliani Health Polytechnic of Kupang
Keywords: Solanum Betaceum, Diabetic Rats, Alloxan, Antihyperglycemic

Abstract

Tamarillo (Solanum betaceum) is one of the plants in Indonesia and is often used by humans for various diseases, one of the chemical ingredients of Tamarillo is flavonoids which are efficacious as alternative antidiabetic drugs. This study aims to determine the effect of Tamarillo syrup (Solanum betaceum) on reducing blood glucose levels in diabetic rats that are induced by intraperitoneal alloxan and find out the effective dose in reducing blood glucose levels. The animals tested were divided into 5 groups, each group consisted of 5 male white rats, namely Group 1 diabetes control (CMC 0.5%), comparison control group II (glibenclamide), and group III, IV, V given tamarillo syrup in a row 200 mg / kg body weight, 400 mg / kg body weight, and 600 mg / kg body weight. All groups were induced with alloxan on day 0 (after 17 hours fasting) intraperitoneally. Examination of blood sugar levels was carried out on the 4th, 7th, 10th and 14th days after administration of the test preparation. The result of test showed that Tamarillo syrup had antihyperglycemic activity. Tamarillo syrup 3 dose variations can reduce blood glucose levels. The dosage of 200 mg / kgBB and 600 mg / kgBB has a significant effect on reducing glucose levels but giving a dose of 400 mg/ kgBB gives less optimal results. The larger dose of Dutch eggplant syrup is followed by a significant increase in the antihypergicemic effect.

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Published
2018-12-31
How to Cite
Yuliani, N. (2018). Antihiperglicemic Activity Tests OF Tamarillo (Solanum Betaceum) on Aloksan’s Diabetes Rats. Proceeding 1st. International Conference Health Polytechnic of Kupang, 373-383. Retrieved from http://proceeding.poltekeskupang.ac.id/index.php/ichpk/article/view/65